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Title   소아 중추신경계 Primitive Neuroectodermal Tumor 에 대한 ' 8-drugs-in-a-day ' 항암요법 ( Experience of ' 8-drugs-in-a-day ' Chemotherapy for CNS Primitive Neuroectodermal Tumor )
Publicationinfo   1993 Jan; 025(05): 707-717.
Key_word   Medulloblastoma, PNET(Primitive Neuroectodermal Tumar), Chemotherapy, S-drugs-in-a-day, Survival rate
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Abstract   Medulloblastoma(MB) and primitive neuroectodermal tumor(PNET) are the most common posterior fossa tumors in childhood. Despite surgery and radiation therapy, 40-50% of children with MB & PNET have recurred. Between 1986 and 1992, 35 patients with newly diagnoaed MB or PNET were treated postoperatively with CCG 921 '8-drugs-in-a-day protocol at the authors' institution. Among them, 19 patients had taken the pre-RT chemotherapy, and the remained 16 patients only the post-RT chemotherapy. The overall 5 year survival rate was 61%. The 5 year SR for the patients treated with pre-RT chemotherapy and without pre-RT chemotherapy were 54%, 69% respectively. Its difference was not significant(P=0.32). It is probably due to short follow-up time and smal1 number of the patients. Further investigation of the efficacy of chemotherapeutic drugs as adjuvant chemotherapy in newly diagnosed MB & PNET is necessary.
저 자   신희영(Hee Young Shin),안효섭(Hyo Seop Ahn)